'And they knew that they were naked.' Nakedness in the Middle Ages

In Anlehnung an die berühmte Kontroverse zwischen Nobert Elias und Hans Peter Duerr um die Frage der Entstehung der Schamgrenzen im Verhältnis von Körper und Kultur wendet sich dieser Sammelband in inter- und transdisziplinärer Weise der 'Nacktheit im Mittelalter' zu. In 18 Beiträgen aus der gesamten Bandbreite geisteswissenschaftlicher Disziplinen (Geschichte, Islamwissenschaften, Kunstgeschichte, Latinistik, Literaturwissenschaften, Theologie und Philosophie) werden verschiedenste Aspekte entblößter Körper behandelt und umfassend, teilweise mit reichem Bildmaterial dargestellt.folg

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants : a Prospective Lynch Syndrome Database report

Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR (path_MMR) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and death in 1%, 2%, 0%, and 0%, respectively. Risk-reducing hysterectomy at 40 years prevents endometrial cancer by 50 years in 13%, 16%, 11%, and 0% and death in 1%, 2%, 1%, and 0%, respectively. BSO at 40 years prevents ovarian cancer before 50 years in 4%, 8%, 0%, and 0%, and death in 1%, 1%, 0%, and 0%, respectively. Conclusion Little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality. These findings may aid decision making for women with LS who are considering RRS.Peer reviewe